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Azido-PEG10-acid

Azido-PEG10-acid Structure
Azido-PEG10-acid
  • CAS No.1644163-57-4
  • Chemical Name:Azido-PEG10-acid
  • CBNumber:CB03062335
  • Molecular Formula:C23H45N3O12
  • Formula Weight:555.62
  • MOL File:1644163-57-4.mol
Azido-PEG10-acid Property
  • solubility Soluble in Water, DMSO, DMF
Safety
  • HS Code  :2918999090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Azido-PEG10-acid Chemical Properties,Usage,Production

  • Description Azido-PEG10-acid is a water soluble PEG compound containing an azide group with a terminal carboxylic acid. The azide (N3) group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
  • Uses Azido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG10-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
  • IC 50 PEGs
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG10-acid Preparation Products And Raw materials
Raw materials
Preparation Products
Azido-PEG10-acid Suppliers
Global(41)Suppliers
  • Supplier：
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  • Supplier： Alabiochem Tech.Co., Ltd.
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Azido-PEG10-acid Spectrum
1644163-57-4, Azido-PEG10-acidRelated Search:
  • peg
  • PEG系列产品-N3-PEG系列
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  • 1644163-57-4
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