ChemicalBook > CAS DataBase List > Ald-PEG5-Azide

Ald-PEG5-Azide

Ald-PEG5-Azide Structure
Ald-PEG5-Azide
  • CAS No.1446282-38-7
  • Chemical Name:Ald-PEG5-Azide
  • CBNumber:CB03062300
  • Molecular Formula:C12H23N3O6
  • Formula Weight:305.33
  • MOL File:1446282-38-7.mol
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Ald-PEG5-Azide Chemical Properties,Usage,Production

  • Description Ald-CH2-PEG5-azide is a click chemistry crosslinker containing an azide group and an aldehyde group. The azide group enables PEGylation via Click Chemistry. PEG5 arm increases solubility in aqueous media. The aldehyde group reacts with amines and the N-terminal of peptides and proteins to form an imine containing a C=N double bond, which can be further reduced.
  • Uses Ald-CH2-PEG5-azide is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Ald-CH2-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
  • Biological Activity Ald-CH2-PEG5-azide is a non-cleavable ADC linker containing 5-unit PEG that can be used to synthesize antibody drug conjugates (ADCs).
  • target

    Non-cleavable

    < span>

  • IC 50 Non-cleavable Linker
  • References [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
Ald-PEG5-Azide Preparation Products And Raw materials
Raw materials
Preparation Products
Ald-PEG5-Azide Suppliers
Global(21)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Chongqing Chemdad Co., Ltd
  • Tel：+86-023-6139-8061<br/>+86-86-13650506873
  • Email：sales@chemdad.com
  • Country：China
  • ProdList：39927
  • Advantage：58
Ald-PEG5-Azide Spectrum
1446282-38-7, Ald-PEG5-AzideRelated Search:
  • peg
  • 小分子药物
  • 醛基-亚甲基-五聚乙二醇-叠氮
  • 醛基-五聚乙二醇-叠氮
  • 叠氮-五聚乙二醇-乙醛
  • 1446282-38-7
  • N3-PEG5-CH2CHO
  • CHO-PEG5-azide
  • Ald-CH2-PEG5-N3
  • ALD-CH2-PEG5-AZIDE
  • Ald-PEG5-Azide

Home

My