(RS)-1-Amino-5-phosphonoindan-1-carboxylic acid

Uses

(RS)-APICA is a group II metabotropic glutamate receptor antagonist.

Biological Activity

The rigidified analog of MPPG ((RS)-a-Methyl-4-phosphonophenylglycine ); a selective group II metabotropic glutamate receptor antagonist (IC 50 = 30 μ M) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses an unusual inverse agonist-like action.

IC 50

mGluR2