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HYPERFORIN

HYPERFORIN Structure
HYPERFORIN
  • CAS No.11079-53-1
  • Chemical Name:HYPERFORIN
  • CBNumber:CB0273398
  • Molecular Formula:C35H52O4
  • Formula Weight:536.78
  • MOL File:11079-53-1.mol
HYPERFORIN Property
  • Melting point 79-80℃
  • alpha D18 +41° (in ethanol)
  • Boiling point 616.8±55.0 °C(Predicted)
  • Density 1.010±0.06 g/cm3 (20 ºC 760 Torr)
  • Flash point 9℃
  • storage temp. -20°C
  • form solution
  • pka 4.8 (50% aq ethanol)
  • CAS DataBase Reference 11079-53-1
  • FDA UNII RM741E34FP
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H225-H301+H311+H331-H370
  • Precautionary statements P210-P280-P301+P310+P330-P302+P352+P312-P304+P340+P311
HYPERFORIN Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: H5160
  • Product name : Hyperforin
  • Purity: ≥85% (HPLC)
  • Packaging: 250μG
  • Price: ₹23421.3
  • Updated: 2022/06/14
  • Buy: Buy

HYPERFORIN Chemical Properties,Usage,Production

  • Uses St. John’s wort is a widely consumed herbal preparation which has been claimed to have a number of medicinal properties. It contains a number of known lipid signalling mediators, including chlorogenic acid, hypericin, hyperforin, and I3,II8-biapigenin. Hyperforin exhibits two activities which may alter the action of other concurrent medications. It inhibits the activity of several CYP450 enzymes, with CYP2D6 being the most sensitive with an IC50 of about 10 μg/ml. Hyperforin is also a ligand for the steroid X receptor (SXR). Since one activity of this receptor is the induction of CYP450 expression, the exact nature of hyperforin’s drug-drug interactions must be evaluated on a case-by-case basis. However, these interactions certainly complicate its use as a human therapeutic.[Cayman Chemical]
  • Uses Hyperforin may be used:
    • as a reference standard for calibration curve generation in high-perfornamce liquid chromatography (HPLC) analysis
    • to test its cytotoxic effect and apoptosis induction in mouse embryonic cells
    • as a pregnane X receptor (PXR) in porcine brain capillary endothelial cells for transport assay

  • Definition ChEBI: A cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. John's Wort, Hypericum perforatum.
  • General Description Hyperforin is a phloroglucinol component of St. John′s wort and a pregnane X receptor ligand.
  • Biochem/physiol Actions Hyperforin is an active antidepressant and an inhibitor of cytochrome P450 3A4 (CYP3A). It elicits antioxidant and antibacterial activity. Hyperforin is also embryotoxic and inhibits tumor proliferation. It effectively inhibits dopamine, serotonin and norepinephrine.
  • in vivo

    Hyperforin (5 mg/kg; i.p.; once daily for 7 d) ameliorates Imiquimod.html" class="link-product" target="_blank">Imiquimod (HY-B0180)-induced psoriatic skin lesion in mice, as well as inhibiting inflammatory cell infiltration and inflammatory cytokines release[3].

    Animal Model:IMQ-induced psoriasis-like mice model[3]
    Dosage:5 mg/kg
    Administration:Intraperitoneal injection; once daily for 7 days
    Result:Significantly ameliorated skin lesion throughout the treatment period, demonstrated by the reduced severity score of skin inflammation.
    Suppressed infiltration of CD3+ T cells and downregulated expression of Il1, Il6, Il23, Il17a, Il22, antimicrobial peptides (AMPs) in the skin lesion.
HYPERFORIN Preparation Products And Raw materials
Raw materials
Preparation Products
HYPERFORIN Suppliers
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HYPERFORIN Spectrum
11079-53-1, HYPERFORINRelated Search:
  • Miscellaneous Natural Products
  • Pharmacologicals
  • Isoprenoid/terpenoid
  • Cancer Research
  • Biochemicals Found in Plants
  • Antitumor Agents
  • Anti-Proliferative AgentsNeurobiology
  • AntidepressantsNutrition Research
  • 杂质对照品
  • 抑制剂
  • 天然产物
  • 有机原料
  • 植物提取类
  • 对照品
  • Cancer Research
  • Antitumor Agents
  • Anti-Proliferative Agents
  • BioChemical
  • C35H52O4
  • HYPERFORIN DICYCLOHEXYLAMMONIUM SALT,ACTIVE CONSTITUENT OF ST. JOHN#39S WORT
  • 贯叶金丝桃素混合物 [干冰运输]
  • 贯叶金丝桃素/间苯三酚类
  • HYPERFORIN MIX(P-基准级,)/干冰运输/保存条件:-80°
  • 贯叶金丝桃素MIX
  • 海穿孔菌素
  • 高含量贯叶金丝桃素
  • 贯叶金丝桃素
  • 11079-53-1
  • Hyperforin - solution in methanol
  • Hyperforin dicyclohexylammonium salt, active constituent of St. John#39s wort
  • HYPERFORIN MIX
  • HYPERFORIN USP/EP/BP
  • Bicyclo[3.3.1]non-3-ene-2,9-dione,4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-
  • Hyperforin (solution in Ethanol)
  • HYPERFORIN MIX(P)
  • (1R,5S)-4-Hydroxy-6-methyl-1,3,7β-tris(3-methyl-2-butenyl)-5-(2-methyl-1-oxopropyl)-6α-(4-methyl-3-pentenyl)bicyclo[3.3.1]non-3-ene-2,9-dione
  • HYPERFORIN
  • 4-HYDROXY-6R-METHYL-1R,3,7S-TRIS(3-METHYL-2-BUTENYL)-5S-(2-METHYL-1-OXOPROPYL)-6R-(4-METHYL-3-PENTENYL)-BICYCLO[3.3.1]NON-3-ENE-2,9-DIONE
  • methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-
  • Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-

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