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N-Ethyl-p-menthane-3-carboxamide

CAS No.39711-79-0
Chemical Name:N-Ethyl-p-menthane-3-carboxamide
CBNumber:CB0252522
Molecular Formula:C13H25NO
Formula Weight:211.34
MOL File:39711-79-0.mol

N-Ethyl-p-menthane-3-carboxamide Property

Melting point 87-102 °C
alpha D -49 to -54°
Boiling point 351.04°C (rough estimate)
Density 0.9305 (rough estimate)
vapor pressure 0.007Pa at 25℃
refractive index 1.4410 (estimate)
FEMA 3455 | N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE
storage temp. Sealed in dry,Room Temperature
solubility DMSO: ≥ 100 mg/mL (473.17 mM); Water: < 0.1 mg/mL (insoluble)
pka 16.27±0.60(Predicted)
form powder to crystal
color White to Almost white
Odor at 25.00 % in dipropylene glycol. mild mentholic minty
Odor Type minty
biological source synthetic
Water Solubility insoluble
Merck 14,3825
JECFA Number 1601
InChIKey VUNOFAIHSALQQH-UHFFFAOYSA-N
LogP 2.902 at 25℃
CAS DataBase Reference 39711-79-0(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE
EWG's Food Scores 1
FDA UNII 6S7S02945H
EPA Substance Registry System Cyclohexanecarboxamide, N-ethyl-5-methyl-2-(1-methylethyl)- (39711-79-0)
UNSPSC Code 12164502
NACRES NA.21

Safety

Hazard Codes :Xi,Xn
Risk Statements :36-41-22
Safety Statements :39-26
WGK Germany :2
HS Code :29242990
Toxicity :LD50 in mice, rats (g/kg): 5.3, 2.9 orally (Parrish)

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H302-H318
Precautionary statements P264-P270-P280-P301+P312-P305+P351+P338-P501

N-Ethyl-p-menthane-3-carboxamide Price More Price(8)

Brand: Sigma-Aldrich(India)
Product number: W345501
Product name : N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
Purity: 99%, FG
Packaging: 1SAMPLE-K
Price: ₹5141.88
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: W345501
Product name : N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
Purity: 99%, FG
Packaging: 100G
Price: ₹15295.73
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: W345501
Product name : N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
Purity: 99%, FG
Packaging: 1KG
Price: ₹72992.98
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: W345501
Product name : N-Ethyl-2-isopropyl-5-methylcyclohexanecarboxamide
Purity: 99%, FG
Packaging: 5KG
Price: ₹260449.5
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: E0796
Product name : N-Ethyl-p-menthane-3-carboxamide
Purity: min. 98.0 %
Packaging: 5G
Price: ₹2700
Updated: 2022/05/26
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N-Ethyl-p-menthane-3-carboxamide Chemical Properties,Usage,Production

Chemical Properties Slight menthol-like cooling effect aroma
Chemical Properties white crystalline powder
Chemical Properties N-ethyl-p-menthane-3-carboxamide is an odorless white, crystalline solid. The compound has a strong and clear physiological cooling effect and is used mainly in oral care products.
Uses WS 3 is a selective transient receptor potential melastatin-8 ligand.
Uses Physiological coolant in foods, beverages, toiletries, cosmetics and pharmaceuticals.
Definition ChEBI: Ethyl menthane carboxamide is a p-menthane monoterpenoid.
Aroma threshold values Aroma characteristics at 1.0%. Virtually odorless
Taste threshold values Taste characteristics at 10 to 100 ppm. Intense lingering cooling. The cooling sensation builds slow but steadily and grows to a lingering cooling mouthfeel with a slightly camphoraceous and minty character.
Flammability and Explosibility Not classified
Trade name Winsense WS-3 (Renessenz)
Biological Activity Cooling agent that is an agonist at TRPM8 receptors (EC 50 = 3.7 μ M).
Synthesis 0.89 g (0.0091 mol) of polyphosphoric acid (85%) and 0.42 g (0.0091 mol) of ethanol were weighed. 0.54 g (0.0046 mol) of diethylcarbonate was added dropwise slowly while cooling in an ice bath, wherein the temperature increases slightly. After about 5 minutes, 0.5 g (0.0030 mol) of p-menthane-3-carbonitrile was added. The reaction solution was heated and stirred for 102 hours at 150??C. At the end of the reaction by GC, about 70% of desired N-Ethyl-p-menthane-3-carboxamide was formed.Fig The synthetic method 1 of N-Ethyl-p-menthane-3-carboxamide