Pharmacological action
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Vemakalant

Pharmacological action
Vemakalant Structure
Vemakalant
  • CAS No.794466-70-9
  • Chemical Name:Vemakalant
  • CBNumber:CB02498847
  • Molecular Formula:C20H31NO4
  • Formula Weight:349.46
  • MOL File:794466-70-9.mol
Vemakalant Property
  • Boiling point 479.0±45.0 °C(Predicted)
  • Density 1.14±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO
  • form Powder
  • pka 14.79±0.20(Predicted)
  • FDA UNII 9G468C8B13
  • ATC code C01BG11
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338

Vemakalant Chemical Properties,Usage,Production

  • Pharmacological action Venakaran works by blocking peak sodium currents by blocking overdrive-activated delayed rectifier currents (IKur). IKur, encoded by the Kv1.5 channel protein, is abundantly expressed in atrial myocytes, is the main current mediating atrial repolarization in humans, and is activated during atrial fibrillation. Venakalan inhibition of IKur can prolong the action potential duration of the atrium, thereby prolonging the atrial effective refractory period and slowing down atrial conduction, so as to shorten the time of atrial fibrillation and quickly achieve the effect of atrial fibrillation conversion.
  • Description Vernakalant is a potassium channel blocker that was approved in Europe in 2010 for treatment of atrial fibrillation (AF), a condition of cardiac arrhythmia in which the atria of the heart beat irregularly due to changes in cardiac ion channel function and distribution. Vernakalant has activity for cardiac Na+ and K+ channels and also for the atrial-selective Kv1.5 channel. Vernakalant (RSD1235) was characterized in animal models to assess efficacy, atrial selectivity, and reduction in side effects.
  • Originator Cardiome Pharma Corp. (Canada)
  • Definition ChEBI: Vernakalant is an alcohol and a member of phenols.
  • brand name Brinavess
Vemakalant Preparation Products And Raw materials
Raw materials
Preparation Products
Vemakalant Suppliers
Global(61)Suppliers
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Vemakalant Spectrum
794466-70-9, VemakalantRelated Search:
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  • 794466-70-9
  • Vernakalant (RSD-1235)
  • Vemakalant USP/EP/BP
  • 3-Pyrrolidinol, 1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]-, (3R)-
  • (3R)-1-[(1R,2R)-2-[2-(3,4-Dimethoxyphenyl)ethoxy]cyclohexyl]-3-pyrrolidinol
  • (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol
  • CS-419
  • VERNAKALANT;RSD1235;RSD 1235;RSD-1235
  • Vernakalant Impurity B ((3S, 1'R, 2'R)-Isomer)
  • Vernakalant
  • Vemakalant

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