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LY 334370 HYDROCHLORIDE

LY 334370 HYDROCHLORIDE Structure
LY 334370 HYDROCHLORIDE
  • CAS No.182563-08-2
  • Chemical Name:LY 334370 HYDROCHLORIDE
  • CBNumber:CB02459701
  • Molecular Formula:C21H22FN3O
  • Formula Weight:351.42
  • MOL File:182563-08-2.mol
LY 334370 HYDROCHLORIDE Property
  • Boiling point 479.1±45.0 °C(Predicted)
  • Density 1.267±0.06 g/cm3(Predicted)
  • storage temp. Store at +4°C
  • solubility H2O: ≥5mg/mL (warmed)
  • form powder
  • pka 13.98±0.43(Predicted)
  • color white to tan
  • FDA UNII 5Q7I1WL2UY
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H317-H319
  • Precautionary statements P280-P305+P351+P338

LY 334370 HYDROCHLORIDE Chemical Properties,Usage,Production

  • Uses LY 334370 Hydrochloride is a 5-HT1f receptor agoniist used potentially in the treatment of migranes.
  • Biological Activity Selective 5-HT 1F receptor agonist (K i values are 1.87, 16.4, > 100 (IC 50 ), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC 50 ) and 3250 nM for 5-HT 1F , 5-HT 1A , 5-HT 4 , 5-HT 1E , 5-HT 1B , 5-HT 1D , 5-HT 2B , 5-HT 2A , 5-HT 7 , 5-HT 6 and 5-HT 2C receptors respectively). Displays antimigraine effects.
  • in vivo

    Following intravenous administration of LY334370 at 3 mg/kg (n=3) or 10 mg/kg (n=6) electrical stimulation evokes an increase in dural blood vessel diameter of 135±6% and 106±11%, respectively, which is not significantly different from the respective control values. LY334370 has no effect on dural blood vessel diameter per se, since the actual dural blood vessel diameter is 43±4 arbitrary units before drug and 43±4 arbitrary units 15 min after injection of LY334370 (10 mg/kg)[1].

  • IC 50 5-HT1F Receptor: 1.6 nM (Ki)
LY 334370 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
LY 334370 HYDROCHLORIDE Suppliers
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LY 334370 HYDROCHLORIDE Spectrum
182563-08-2, LY 334370 HYDROCHLORIDERelated Search:
  • 抑制剂
  • C21H22FN3OHCl
  • 化合物LY 334370,10 MM DMSO 溶液
  • 4-氟-N-[3-(1-甲基-4-哌啶基)-1H-吲哚-5-基]苯甲酰胺
  • 4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺
  • 化合物LY 334370
  • 4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐
  • 182563-08-2
  • LY334370, 10 mM in DMSO
  • inhibit,Inhibitor,5-hydroxytryptamine Receptor,LY-334370,LY334370,Serotonin Receptor,5-HT Receptor
  • LY 334370 hydrochlor
  • Y334370
  • Y 334370 HCL
  • LY334370;LY-334370;LY 334370
  • LY 334370 HCL
  • 4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-indol-5-yl]-benzamide
  • LY 334370
  • 4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide hydrochloride
  • 4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benzamide hydrochloride
  • LY-334370 hydrochloride hydrate
  • 4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate
  • BenzaMide, 4-fluoro-N-[3-(1-Methyl-4-piperidinyl)-1H-indol-5-yl]-
  • 4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide
  • 4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamidehydrochloride
  • LY 334370 HYDROCHLORIDE

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