ChemicalBook > CAS DataBase List > 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-

4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-

4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Structure
4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-
  • CAS No.663619-89-4
  • Chemical Name:4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-
  • CBNumber:CB02456412
  • Molecular Formula:C21H24N4O2
  • Formula Weight:364.44
  • MOL File:663619-89-4.mol
4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Property
  • Melting point 198-201oC
  • Boiling point 557.3±60.0 °C(Predicted)
  • Density 1.25±0.1 g/cm3(Predicted)
  • storage temp. Hygroscopic, Refrigerator, under inert atmosphere
  • solubility DMSO (Slightly), Methanol (Very Slightly)
  • pka 3.90±0.50(Predicted)
  • form Pale yellow solid.
  • color Off-White to Pale Yellow
  • FDA UNII 6L28AW98TH
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements
  • Precautionary statements

4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Chemical Properties,Usage,Production

  • Uses TGX-221 is a potent, selective, and cell permeable inhibitor of Phosphatidylinositol 3-kinase (PI3K) p110β.
  • Definition ChEBI: 9-(1-anilinoethyl)-7-methyl-2-(4-morpholinyl)-4-pyrido[1,2-a]pyrimidinone is a pyridopyrimidine.
  • General Description A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kβ (IC50 = 0.005, 0.1, 5, and ≥3.5 μM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 μM. An excellent tool for studying p110β-dependent responses both in cells in vitro and in animals in vivo.
  • Biological Activity tgx-221 is a potent inhibitor of (phosphatidylinositol 3-kinases) pi3k which specifically inhibits pi3k -p110β isoform with ic50 value of 8.5 nm [1].in j774.2 macrophage cells, tgx-221 has been demonstrated to reduce insulin-induced phosphorylation of ser473 of protein kinase b (pkb). while in in cho-ir and 3t3-l1 cells, tgx-221 has no effect on pkb phosphprylation [1].
  • Biochem/physiol Actions Cell permeable: yes
  • in vivo tgx-221 significantly improved blood flow in fecl3-induced arterial thrombosis as well as increased tail and renal bleeding times in mice. in addition, tgx-221 has revealed to disrupt cfrs in a folts model of arterial thrombosis in male sprague-dawley rats [2].
  • storage Store at -20°C
  • References [1] chaussade c1, rewcastle gw, kendall jd, denny wa, cho k, gr nning lm, chong ml, anagnostou sh,jackson sp, daniele n, shepherd pr. evidence for functional redundancy of class ia pi3k isoforms in insulin signalling. biochem j. 2007 jun 15;404(3):449-58.
    [2] bird je1, smith pl, bostwick js, shipkova p, schumacher wa. bleeding response induced by anti-thrombotic doses of a phosphoinositide 3-kinase (pi3k)-β inhibitor in mice. thromb res. 2011 jun;127(6):560-4.
4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Preparation Products And Raw materials
Raw materials
Preparation Products
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4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- Spectrum
663619-89-4, 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-Related Search:
  • PI3K
  • mTOR
  • Akt
  • Inhibitors
  • 抑制剂
  • 生物试剂
  • 合成有机化合物配体
  • 细胞生物学试剂
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • 化合物TGX-221,10 MM DMSO 溶液
  • 化合物TGX-221
  • 7-甲基-2-吗啉-9-(1-(苯基氨基)乙基)-4H-吡啶[1,2-A]嘧啶-4-酮
  • 7-甲基-2-(吗啉-4-基)-9-[1-(苯氨基)乙基]吡啶并[1,2-A]嘧啶-4-酮
  • PI3K P110Β抑制剂(TGX-221)
  • (+/-)-7-甲基-2-(吗啉-4-基)-9-(1-苯基氨基乙基)吡啶并[1,2-A]嘧啶-4-酮
  • 663619-89-4
  • TGX-221, 10 mM in DMSO
  • TGX-221, PI3K inhibitor
  • TGX-221 PI3K inhibitor ab120924
  • 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- ISO 9001：2015 REACH
  • 9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one
  • TGX221; TGX221; TGX 221.
  • TGX-221, PI3K Inhibitor (&plusmn
  • TGX-221; TGX 221
  • CS-429
  • PI 3-Kβ Inhibitor VI, TGX-221
  • TGX 221 (+/-)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)pyrido[1,2-a]pyrimidin-4-one
  • (+/-)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)pyrido[1,2-a]pyrimidin-4-one TGX 221
  • 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one
  • (+/-)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)pyrido[1,2-a]pyrimidin-4-one
  • TGX 221
  • 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-

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