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Cinchonine

Cinchonine Structure
Cinchonine
  • CAS No.118-10-5
  • Chemical Name:Cinchonine
  • CBNumber:CB0244972
  • Molecular Formula:C19H22N2O
  • Formula Weight:294.39
  • MOL File:118-10-5.mol
Cinchonine Property
  • Melting point 260-263 °C
  • alpha 224 º (c=0.5, alcohol)
  • Boiling point 436.16°C (rough estimate)
  • Density 1.0863 (rough estimate)
  • bulk density 130kg/m3
  • vapor pressure 0Pa at 25℃
  • refractive index 223 ° (C=0.5, EtOH)
  • storage temp. Keep in dark place,Sealed in dry,Room Temperature
  • solubility 0.25g/l
  • form Micro-Crystalline Powder
  • pka 5.85, 9.92(at 25℃)
  • color White to light beige
  • PH 9.0 (0.25g/l, H2O, 20℃)(as aqueous solution)
  • optical activity [α]23/D +228°, c = 0.5 in ethanol
  • Water Solubility Insoluble
  • Sensitive Light Sensitive
  • Merck 14,2287
  • BRN 89689
  • Stability Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
  • InChIKey KMPWYEUPVWOPIM-QHQSXHFQSA-N
  • LogP 2.82 at 25℃
  • CAS DataBase Reference 118-10-5(CAS DataBase Reference)
  • EWG's Food Scores 1
  • FDA UNII V43X79NZCD
  • NIST Chemistry Reference Cinchonine(118-10-5)
  • EPA Substance Registry System Cinchonan-9-ol, (9S)- (118-10-5)
  • UNSPSC Code 12352104
  • NACRES NA.22
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :20/22-20/21/22
  • Safety Statements  :26-36-36/37
  • RIDADR  :1544
  • WGK Germany  :3
  • RTECS  :GD3500000
  • F  :8-34
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :29339900
  • Toxicity :LD50 i.p. in rats: 152 mg/kg (Johnson, Poe)
  • NFPA 704:
    1
    2 1
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H317
  • Precautionary statements P261-P264-P270-P280-P301+P312-P302+P352
Cinchonine Price More Price(13)
  • Brand: Sigma-Aldrich(India)
  • Product number: 857270
  • Product name : (+)-Cinchonine
  • Purity: 85%
  • Packaging: 25G
  • Price: ₹4286.7
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 857270
  • Product name : (+)-Cinchonine
  • Purity: 85%
  • Packaging: 100G
  • Price: ₹8854.85
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 8.02506
  • Product name : (+)-Cinchonine
  • Purity: for resolution of racemates for synthesis
  • Packaging: 25G
  • Price: ₹6750.01
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 8.02506
  • Product name : (+)-Cinchonine
  • Purity: for resolution of racemates for synthesis
  • Packaging: 100G
  • Price: ₹17299.99
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 27370
  • Product name : Cinchonine
  • Purity: crystallized, ≥98.0% (NT)
  • Packaging: 25G
  • Price: ₹4957.85
  • Updated: 2022/06/14
  • Buy: Buy

Cinchonine Chemical Properties,Usage,Production

  • Description Cinchonine is a cinchona alkaloid generally found in the bark of Cinchona officinalis plants. It is a pseudoenantiomer that is commonly employed in malaria therapy. Cinchonine is also used as an organocatalyst in many asymmetric reactions. It is a stereoisomer and pseudo-enantiomer of cinchonidine. It is structurally similar to quinine, an antimalarial drug.
  • Chemical Properties white to light yellow crystal powde
  • Uses Stereomeric with Cinchonidine (C441925). Antimalarial.
  • Uses cardiotonic
  • Uses Cinchonine occurs in most varieties of cinchonabark (Cinchona micrantha and Rubiaceae).It is used as an antimalarial agent.
  • Definition ChEBI: Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (S configuration). It occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.
  • Health Hazard The toxic effects from high doses of cinchonineinclude tinnitus, vomiting, diarrhea, andfever. The toxic effects noted in rats were excitement, change in motor activity, andconvulsions. An intraperitoneal LD50 valuein rats is 152 mg/kg.
  • Flammability and Explosibility Non flammable
  • Purification Methods Crystallise cinchonine from EtOH or diethyl ether. For the N-benzylcinchoninium chloride see above entry in this section. [Rabe Justus Liebigs Ann Chem 365 366, 371 1909, Beilstein 23 III/IV 2819, 2832.]
Cinchonine Preparation Products And Raw materials
Raw materials
Preparation Products
Cinchonine Suppliers
Global(421)Suppliers
  • Supplier：
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  • Email：sales@alchempharmtech.com
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Cinchonine Spectrum
118-10-5, CinchonineRelated Search:
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