Synthesis
N-Chlorosilicate (0.6 mmol, 2.0 equivalent) was added in a single step to a solution of sulfonyl hydrazine (0.3 mmol) in acetonitrile (2 mL). The mixture was stirred at room temperature for 2 hours. The solvent was removed by vacuum evaporation, and the residue was purified by column chromatography (petroleum ether/ethyl acetate) to obtain the target product.
Figure 3: Synthetic route of 3-Bromobenzenesulfonyl chloride
Chemical Properties
clear colorless to yellow liquid
Uses
3-Bromobenzenesulfonyl chloride may be used in the preparation of:
- 2-(3-bromophenyl)-5-n-butylfuran
- 2-(3-bromophenyl)-3,6-dimethyl-4,5,6,7-tetrahydrobenzofuran
- 3-bromo-4-(3-bromophenyl)thiophene
- 2,5-bis(3-bromophenyl)-1-methylpyrrole
General Description
3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of
N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
