Synthesis
Starting with benzaldehyde, a benzothiourea structure is generated through reduction, chlorination, and substitution reactions. Finally, alpha-Toluenesulfonyl chloride is obtained via sulfonyl chloride reaction.
Chemical Properties
almost white crystalline powder
Uses
a-Toluenesulfonyl Chloride inhibits intracellular protein breakdown in the L1210 ascites leukemia in mouse. It also functions as a reagent for the protection of amino groups as benzylsulfonamides which can be cleaved off through reduction.
General Description
Phenylmethanesulfonyl chloride is an aliphatic sulfonyl chloride. It reacts with triethylamine in methylene chloride or ether to yield
trans-stilbene and
cis diphenylethylene sulfone. Its reaction with 1,1-
bis(diethylamino)ethane has been studied. Addition of phenylmethanesulfonyl chloride to 1,3-diphenyl-2-pyrrolidinopropene in the presence of water was studied.
