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Methyl thioglycolate

CAS No.2365-48-2
Chemical Name:Methyl thioglycolate
CBNumber:CB0165491
Molecular Formula:C3H6O2S
Formula Weight:106.14
MOL File:2365-48-2.mol

Methyl thioglycolate Property

Melting point -24 °C
Boiling point 42-43 °C/10 mmHg (lit.)
Density 1.187 g/mL at 25 °C (lit.)
refractive index n20/D 1.466(lit.)
Flash point 86 °F
storage temp. Store below +30°C.
solubility 40g/l
form Liquid
pka 8.04±0.10(Predicted)
color Clear colorless
Odor Strong, unpleasant, garlic-like
Water Solubility 40 g/L (20 ºC)
Sensitive Air Sensitive
BRN 506259
InChIKey MKIJJIMOAABWGF-UHFFFAOYSA-N
CAS DataBase Reference 2365-48-2(CAS DataBase Reference)
EWG's Food Scores 1-3
FDA UNII O1608LA9EL
NIST Chemistry Reference Acetic acid, mercapto-, methyl ester(2365-48-2)
EPA Substance Registry System Acetic acid, mercapto-, methyl ester (2365-48-2)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xn,T
Risk Statements :10-20/22-36/37/38-25
Safety Statements :26-36/37-45-36/37/39-28A
RIDADR :UN 1992 3/PG 3
WGK Germany :1
RTECS :AI7350000
TSCA :Yes
HazardClass :3
PackingGroup :III
HS Code :29309070
Hazardous Substances Data :2365-48-2(Hazardous Substances Data)
Toxicity :mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),National Technical Information Service. Vol. AD277-689,

NFPA 704:

	2
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H226-H301-H315-H319-H332-H335
Precautionary statements P210-P233-P301+P310-P303+P361+P353-P304+P340+P312-P305+P351+P338

Methyl thioglycolate Price More Price(7)

Brand: Sigma-Aldrich(India)
Product number: 108995
Product name : Methyl thioglycolate
Purity: 95%
Packaging: 5G
Price: ₹2294.9
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 108995
Product name : Methyl thioglycolate
Purity: 95%
Packaging: 100G
Price: ₹2413.98
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 108995
Product name : Methyl thioglycolate
Purity: 95%
Packaging: 500G
Price: ₹5066.1
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: T1287
Product name : Methyl Thioglycolate
Purity: min. 98.0 %
Packaging: 25G
Price: ₹1500
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: T1287
Product name : Methyl Thioglycolate
Purity: min. 98.0 %
Packaging: 100G
Price: ₹1900
Updated: 2022/05/26
Buy: Buy

Methyl thioglycolate Chemical Properties,Usage,Production

Chemical Properties CLEAR COLOURLESS LIQUID
Uses Methyl Thioglycolate is an derivative of Thioglycolic Acid (T350760), an organic compound containing both a thiol and a carboxylic acid functional groups. Thioglycolic Acid and its derivatives are oft en used in organic synthesis as a nucleophile in thioglycolysis reactions and is also used as a S transfer agent for sulfonyl chloride synthesis. Methyl Thioglycolate have been studied for the its inf luence on neocarzinostatin activation and expression of DNA damage.
Uses Methyl thioglycolate was used in the preparation of 3-carbomethoxy-4- oxotetrahydrothiopyran, 2- and 4-carbomethoxy-3-oxotetrahydrothiophene. It is used to prepare methyl thioglycolate and aminoethanethiol conjugated gold nanorods.
Production Methods Adding thioglycollic acid with purity of between 70.0 and 96.0 percent and methanol with purity of between 95.0 and 99.9 percent into a reaction device according to the molar ratio of 1:1.3-4.0; subsequently, adding an activating agent into the reaction device, stirring and heating for reaction; and after the reaction is finished, carrying out separatory distillation on reaction products to obtain the methyl thioglycolate. The activating agent is a p-toluenesulfonic acid methanol solution with a mass concentration of between 20 and 30 percent, and the use amount is 0.5 to 1.0 percent of the total mass of relative input materials.
Application Methyl thioglycolate is a chemical compound that is used in the pharmaceutical industry as an intermediate. It has been used to synthesize anti-inflammatory drugs, such as aspirin and ibuprofen, and also for the treatment of autoimmune diseases. Methyl thioglycolate binds to amino acids on the surface of bacteria, which prevents them from functioning properly. This binding causes the cells to stop growing and die.
Definition Methyl thioglycolate are widely used in free-radical photoinitiated polymerization reactions. In particular, the use of methyl thioglycolate (MTG), CH3OC(O)CH2SH, results in greater photopolymerization reaction rates, attributed to a weakening of the sulfur–hydrogen bond by hydrogen bonding of the thiol group. MTG constitutes the smaller exponent of the series of CH3OC(O)(CH2)nSH compounds, reported as intermediated in the organic sulfur cycle in marine environments, produced by marine phytoplankton.
General Description Methyl thioglycolate reacts with nonprotein component of the antitumor antibiotic neocarzinostatin to form 1:1 adduct. It reacts with isothiocyanate to form Rhodanine.
reaction suitability reagent type: ligand
reaction type: [1,2]-Wittig Rearrangement