(S)-5-Iodo-3-[(2-azetidinyl)-methoxy]pyridine

Chemical Properties

Colourless oil

Uses

5-IODO-A-85380 Dihydrochloride is a highly potent and subtype-selective agonist for AChR α4β2 and AChR α6β2.

Biological Activity

A highly potent and subtype-selective agonist for the α 4 β 2 and α 6 β 2 nicotinic acetylcholine receptors. Activates α -CTx-MII-sensitive and -insensitive components of [ 3 H]dopamine release from rat striatal synaptosomes, corresponding to α 6 β 2 and α 4 β 2 (EC 50 values are 12.7 and ~35 nM respectively). ~5000- , 25000- and 140000-fold selective over α 3 β 4, α 7 and muscle nAChR receptors respectively.