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Mitoguazone

Mitoguazone Structure
Mitoguazone
  • CAS No.459-86-9
  • Chemical Name:Mitoguazone
  • CBNumber:CB01179220
  • Molecular Formula:C5H12N8
  • Formula Weight:184.2
  • MOL File:459-86-9.mol
Mitoguazone Property
  • Melting point 225 °C (decomp)
  • Boiling point 323.8±25.0 °C(Predicted)
  • Density 1.55±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • pka 7.63, 9.05(at 25℃)
  • form Solid
  • color Light brown to brown
  • Water Solubility Water: 50 mg/mL (271.44 mM; ultrasonic and adjust pH to 9 with HCl)
  • CAS DataBase Reference 459-86-9
  • FDA UNII OD5Q0L447W
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Mitoguazone Chemical Properties,Usage,Production

  • Uses Mitoguazone has therapeutic applications as a cytotoxic agent.
  • Definition ChEBI: A hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine.
  • in vivo

    The influence of different stages of leukemia P388 on the pharmacokinetics of the antineoplastic agent Mitoguazone in mice is investigated. Independent of the tumor stage investigated, the total clearance of mitoguazone is slightly reduced reflecting a moderate increase of AUC in the serum of leukemia-bearing animals. Furthermore, in an advanced tumor stage the drug levels in kidneys, liver, spleen and serum are found to be elevated to some extent in comparison to tumor-free controls in contrast to an earlier stage of leukemia[5].

Mitoguazone Preparation Products And Raw materials
Raw materials
Preparation Products
Mitoguazone Suppliers
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Mitoguazone Spectrum
459-86-9, MitoguazoneRelated Search:
  • 抑制剂
  • 化学试剂
  • 原料药
  • 原料
  • 化工原料
  • 无机物
  • C5H12N8
  • 2,2'-(丙烷-1,2-二基亚基)双(肼甲脒)
  • 米托瓜酮
  • 米托胍腙(又名盐酸丙脒腙)
  • 丙酮双脒腙
  • 丙双脒腙
  • 459-86-9
  • 2,2'-(Propane-1,2-diylidene)bis(hydrazinecarboximidamide)
  • Mitoguazone USP/EP/BP
  • Hydrazinecarboximidamide, 2,2'-(1-methyl-1,2-ethanediylidene)bis-
  • (2E,2'E)-2,2'-[(1E,2E)-1,2-Propanediylidene]dihydrazinecarboximidamide
  • Methylglycoxali BisguanylhydrazonuM
  • Mitoguazone(Methyl-GAG)
  • Pyruvaldehyde bis(amidinohydrazone)
  • MGBG
  • Me-GAG
  • 2,2'-(1-Methyl-1,2-ethanediylidene)bis(hydrazinecarbimidamide)
  • methyl-gag
  • methyl-g
  • 2,2'-(1-methyl-1,2-ethanediylidene)bis-hydrazinecarboximidamid
  • 1,1'-((methylethanediylidene)dinitrilo)diguanidine
  • 1,1'-((methylethanediylidene)dinitrilo)di-guanidin

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