Cafedrine

Originator

Praxinor,Merck Lipha Sante

Uses

(-)-Cafedrine is composed of linked Phenylpropanolamine (P336100) and Theophylline (T343850). It is used to regulate and restore blood pressure.

Manufacturing Process

7.5 g 7-(2-bromethyl)theophylline, 11.3 g 1-norphedrine and 12.5 ml isopropanol were refluxed with stirring for 6 hours. Then 30 ml ethanol and HCl in ethanol to pH 5-6 were added. The mixture stood for 2 days. 9.6 g of 7-(2-(beta-hydroxy-alpha-methylphenethylamino)ethyl)theophylline hydrochloride was filtered off and dried. MP 243°-244°C.
In practice it is usually used as free base.

Therapeutic Function

Analeptic