Chemical Properties
Clear transparent liquid
Uses
Chloromethyltrimethoxysilane may be used in the preparation of 1-methyl-1H-benzimidazole (MBI)-modified nanoparticles.{33} Mesoporous monolithic silica gels can also be prepared from Chloromethyltrimethoxysilane. {34}
General Description
Chloromethyltrimethoxysilane (CMTMS) is a trialkoxysilane with chloromethyl as the organofunctional group having hydrophobic characteristics. Chloromethyl is the electron withdrawing group that improves the mechanical properties of the molecule. CMTMS is mainly utilized as a silane based precursor material for the preparation of surface enhancement based coatings and other silane based products.
Synthesis
The general procedure for the synthesis of chloromethyltrimethoxysilane from chloromethyltrichlorosilane and trimethyl orthoformate was as follows: 570.2 g (3.1 mol) of chloromethyltrichlorosilane was slowly added dropwise to 1127.8 g (10.64 mol) of trimethyl orthoformate, and the dropwise acceleration was controlled so that the reaction mixture was kept at a slight boiling state. After the dropwise addition was completed, the reaction system was heated to 90°C and the reaction was maintained at this temperature for 5 hours. Upon completion of the reaction, the reaction mixture was purified by distillation, resulting in 449.8 g of the target product chloromethyltrimethoxysilane (Compound 2a). The structure of the product was confirmed by 1H NMR spectrum with the following chemical shifts δ (ppm): 2.77 (single peak, 2H, CH2), 3.58 (single peak, 9H, OCH3).
References
[1] Russian Journal of General Chemistry, 2016, vol. 86, # 8, p. 1859 - 1863
[2] Zh. Obshch. Khim., 2016, vol. 86, # 8, p. 1321 - 1326,6
