Synthesis
GENERAL METHOD: Compound 2d (302 mg, 0.516 mmol) was dissolved in ethanol (10 mL), followed by the addition of a solution of silver nitrate (AgNO3, 369 mg, 2.17 mmol) in water (4 mL). The reaction mixture was heated to reflux for 40 min under argon protection. Upon completion of the reaction, it was cooled to room temperature, the resulting silver bromide (AgBr) was removed by filtration, and the filter cake was washed with ethanol (2 x 5 mL). The solvent was removed by evaporation under reduced pressure and the residue was purified by recrystallization from hexane to give the target product 3d (146 mg, 94% yield) as a white solid.
References
[1] Journal of Organic Chemistry, 2004, vol. 69, # 6, p. 2024 - 2032
[2] Synthesis (Germany), 2016, vol. 48, # 20, p. 3509 - 3514
[3] Tetrahedron, 2013, vol. 69, # 7, p. 1904 - 1911
[4] Journal of Chemical Research, Synopses, 1995, # 10, p. 410 - 411
[5] Journal of Organometallic Chemistry, 2014, vol. 761, p. 28 - 31
