Description
2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1?2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3? Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4
Chemical Properties
BROWN-PURPLE FINE CRYSTALLINE POWDER
Uses
N-1H-Benzimidazol-2-ylguanidine is used as a reagent in the synthesis of novel fused pyrimidines and imidazoles as potential analgesics.
Definition
ChEBI: 2-Benzimidazolylguanidine is an aminoimidazole.
References
1) Hong?et al. (2015),?Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep.,?5?14077
2) Hong?et al.?(2014),?Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA,?111?9971
3) Gianti?et al. (2016),?On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA,?113?E8359
4) Pupo and Gonzalez (2014),?In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA,?111?9673
