Synthesis
1-(4-fluorophenyl)-2-thiourea can be prepared in a one-step reaction using ammonium thiocyanate and 4-fluoroaniline as starting materials. The reaction formula is shown in the figure below:
Figure 1: Reaction formula for the preparation of 1-(4-fluorophenyl)-2-thiourea
In a 50 mL reaction flask equipped with an electromagnetic stirrer, ammonium thiocyanate, 4-fluoroaniline dichloromethane, and PEG-400 were added. The mixture was stirred at room temperature for 1 hour, and then 10 mL of water was added to dissolve the inorganic salts in the reaction mixture. The precipitate was collected by filtration, dried, and recrystallized from it using a mixed solvent of N,N-dimethylformamide, ethanol, and water to give the product 1-(4-fluorophenyl)-2-thiourea.
