Synthesis
Synthesis of 2,6-dimethylisonicotinic acid: A mixture of 4-cyano-2,6-dimethylpyridine (0.5 g, 3.78 mmol), sodium hydroxide (2.5 M, 3 ml) and ethanol (3 ml) was reacted at 100 °C for 5 hours. After cooling to room temperature, the solution was concentrated under vacuum and acidified to pH 3 with 10% hydrochloric acid. After evaporation to dryness, 2,6-dimethylisonicotinic acid was obtained[1].
References
[1] Sophie Laurent. (2014). Bifunctional Gd(III) and Tb(III) chelates based on a pyridine–bis(iminodiacetate) platform, suitable optical probes and contrast agents for magnetic resonance imaging. Contrast Media & Molecular Imaging, 9 4, 300–312. https://doi.org/
10.1002/cmmi.1576
