ChemicalBook CAS DataBase List Naphthol as-e phosphate

Naphthol as-e phosphate

Product NameNaphthol as-e phosphate
CAS18228-17-6
CBNumberCB9737978
MFC17H13ClNO5P
MW377.72
EINECS242-106-1
MDL NumberMFCD00042718
MOL File18228-17-6.mol
MSDS FileSDS

Chemical Properties

Density	1.567±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO: soluble
form	A crystalline solid
pka	1.04±0.30(Predicted)
color	White to light yellow
BRN	6664478
Major Application	histology
InChI	1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
InChIKey	RQAQWBFHPMSXKR-UHFFFAOYSA-N
SMILES	OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3
FDA UNII	H6R6B93QFC
UNSPSC Code	12352204
NACRES	NA.83

Safety

WGK Germany	3
F	8-10-21
Storage Class	11 - Combustible Solids

Naphthol as-e phosphate Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich 70485	250mg	$116	Naphthol AS-E phosphate for histology	Buy
Cayman Chemical 33602	5mg	$69	Naphthol AS-E Phosphate ≥98%	Buy
Cayman Chemical 33602	10mg	$120	Naphthol AS-E Phosphate ≥98%	Buy
Cayman Chemical 33602	25mg	$263	Naphthol AS-E Phosphate ≥98%	Buy
Biosynth EN69791	1000mg	$210	Naphthol AS-E phosphate, 60%	Buy

Naphthol as-e phosphate Chemical Properties,Usage,Production

Uses

Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis th at oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).

Biological Activity

Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.

in vitro

Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.

in vivo

Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.

target

Preparation Products And Raw materials

Naphthol as-e phosphate Supplier

Target	Value
CREB ()

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	87240	60
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	9779	55
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	7996	62
Beijing Solarbio Science & Tecnology Co., Ltd.	17801761073 18101056239	3193328036@qq.com	China	28149	68
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Medi-tech Bioscientific Co., Ltd.	0519-83246372 13585352506		China	1838	58
Chuzhou KeMail Chemical Technology Co., Ltd	0550-5196001 15000891977	wj520wjxby@126.com	China	1941	55

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