Description
ACTH (1-16) is a peptide fragment of adrenocorticotropic hormone (ACTH; Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response.1 It binds to melanocortin receptors (MCRs; Kis = 0.267, 19, 698, and 2,600 nM for MC1R, MC3R, MC4R, and MC5R, respectively).2 ACTH (1-16) (160 µg/kg, i.v.) increases mean arterial blood pressure (MAP) following bleeding-induced hypotension in a rat model of hemorrhagic shock 15-30 minutes after administration.3 It increases grooming behavior and the incidence of stretching and yawning syndrome (SYS) in rats when administered intraventricularly at 0.05 or 2 μg.4WARNING This product is not for human or veterinary use.
References
[1] F L STRAND. Non-corticotropic ACTH peptides modulate nerve development and regeneration.[J]. Reviews in the Neurosciences, 1993, 4 4: 321-363. DOI:
10.1515/revneuro.1993.4.4.321[2] H B SCHIÖTH. The melanocortin 1, 3, 4 or 5 receptors do not have a binding epitope for ACTH beyond the sequence of alpha-MSH.[J]. Journal of Endocrinology, 1997, 155 1: 73-78. DOI:
10.1677/joe.0.1550073[3] ALFIO BERTOLINI. α-MSH and other ACTH fragments improve cardiovascular function and survival in experimental hemorrhagic shock[J]. European journal of pharmacology, 1986, 130 1: Pages 19-26. DOI:
10.1016/0014-2999(86)90179-2[4] WILLEM HENDRIK GISPEN . The induction of excessive grooming in the rat by intraventricular application of peptides derived from ACTH: Structure-activity studies[J]. Life sciences, 1975, 17 4: Pages 645-652. DOI:
10.1016/0024-3205(75)90103-4
