Description
Adrenocorticotropic hormone (ACTH) (4-10) is an endogenous peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response.1 ACTH (4-10) is found in the septal nuclei, the third ventricle, and ventral horn motor neurons.1,2 The amino acid sequence of ACTH (4-10) is common to ACTH and the α- and β-melanocyte stimulating hormones.3 ACTH (4-10) is an agonist of melanocortin receptor 3 (MC3R) and MC4R (EC50s = 23 and 330 nM for the human recombinant receptors, respectively). It increases mean arterial pressure (ED50 = 287 nmol/kg) and heart rate (ED50 = 313 nmol/kg) in rats.4 It also improves aortic and coronary blood flow and left ventricular developed pressure following cardiac ischemia and reperfusion when administered at a dose of 200 µg/kg in rats, as well as reduces the infarct size and decreases caspase-3 activity.5 ACTH (4-10) (10 µg per animal) accelerates motor function improvements in a rat model of sciatic nerve crush.2WARNING This product is not for human or veterinary use.
References
[1] F L STRAND. Non-corticotropic ACTH peptides modulate nerve development and regeneration.[J]. Reviews in the Neurosciences, 1993, 4 4: 321-363. DOI:
10.1515/revneuro.1993.4.4.321[2] STRAND F L. David and Goliath — the slingshot that started the neuropeptide revolution[J]. European journal of pharmacology, 2000, 405 1: Pages 3-12. DOI:
10.1016/s0014-2999(00)00536-7[3] H MIWA. Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors.[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 273 1: 367-372.
[4] PATRICIA VAN BERGEN . Cardiovascular effects of γ-MSH/ACTH-like peptides: structure-activity relationship[J]. European journal of pharmacology, 1995, 294 2: Pages 795-803. DOI:
10.1016/0014-2999(95)00657-5[5] BELA JUHASZ. Adrenocorticotrope hormone fragment (4-10) attenuates the ischemia/reperfusion-induced cardiac injury in isolated rat hearts.[J]. Antioxidants & redox signaling, 2007, 9 11: 1851-1861. DOI:
10.1089/ars.2006.1535
