ER-27319

Uses

ER 27319 Maleate is a PLK-1 and Syk inhibitor.

Biological Activity

Selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of Fc ε RI in rat and human mast cells. Results in the abrogation of degranulation, TNF- α production (IC 50 = 10 μ M) and other related signaling events.