Description
Alprazolam is a benzodiazepine with anxiolytic and sedative actions. 4-
Hydroxyalprazolam is a major metabolite of alprazolam, produced by the actions of cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5. It may be detected in serum or, in a glucuronidated form, in urine. Alternatively, 4-
hydroxyalprazolam can be further metabolized to benzophenone.
Chemical Properties
White Solid
Uses
A metabolite of Alprazolam, a benzodiazepine.
Controlled Substance
Definition
ChEBI: 4-Hydroxyalprazolam is a triazolobenzodiazepine.
References
[1] NORIKO HIROTA. In Vitro/in Vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans[J]. Biopharmaceutics & Drug Disposition, 2001, 22 2: 53-71. DOI:
10.1002/bdd.261[2] J ANDREW WILLIAMS. Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.[J]. Drug Metabolism and Disposition, 2002, 20 1: 883-891. DOI:
10.1124/dmd.30.8.883
