Uses
MU380 is a potent and selective CHK1 inhibitor that induces apoptosis and has anticancer activity[1].
Biological Activity
MU380 is a metabolically stable analog of CHK1 inhibitor SCH900776 (MK8776) does not undergo in vivo N-dealkylation. MU380 is a potent and selective CHK1 inhibitor, which potently sensitizes multiple cancer cell lines to DNA antimetabolites including hydroxyurea, cytarabine and gemcitabine.
in vivo
MU380 (20 mg/kg, in 20% aqueous Kolliphor solution, every three days from day 14 to day 28) can effectively inhibit tumor growth in NOD-scidIL2Rγnullmice with tumour[1].
| Animal Model: | NOD-scidIL2Rγnullmice[1] |
| Dosage: | 20 mg/kg |
| Administration: | In 20% aqueous Kolliphor solution, every three days from day 14 to day 28 |
| Result: | Significantly inhibit the growth of tumors and gradually reduce their volume, with an average reduction of about 61%. |
References
[1] Miroslav Boudny, et al. Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells. Haematologica. 2019 Dec;104(12):2443-2455. DOI:
10.3324/haematol.2018.203430
