Uses
N-Boc-2-pyrrolidinone is a useful synthetic intermediate. It can be used to prepare highly functionalized N-acyl-2-vinylpyrrolidines by a 4-component Ugi reaction (isocyanide, carbonyl compounds, primary amines, carboxylic acids). It can also be used to synthesize the naturally occurring Maillard flavors via catalytic SeO2 oxidation.
General Description
The kinetics of gas-phase elimination of 1-(
tert-butoxycarbonyl)-2-pyrrolidinone has been investigated in a static system. The observed rate coefficient has been reported to be log
k1(s
-1) = (11.54 ± 0.29) -(140.8 ± 2.8)-kJmol
-1 (2.303RT)
-1.