Description
Thromboxane B
2 (TXB
2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-
dehydro TXB
2 and 2,3-
dinor TXB
2. In rats and rabbits, 2,3-
dinor TXB
1 has been identified as another urinary metabolite of TXB
2. However in human urine, only trace amounts of 2,3-
dinor TXB
1 have been identified. In rats, 2,3-
dinor TXB
1 is excreted at a much higher rate than 2,3-
dinor TXB
2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively). Therefore, urinary 2,3-
dinor TXB
1 is a suitable marker of thromboxane biosynthesis in rats.
