196493-76-2

Thromboxane B₂ (TXB₂) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB₂ and 2,3-dinor TXB₂. In rats and rabbits, 2,3-dinor TXB₁ has been identified as another urinary metabolite of TXB₂. However in human urine, only trace amounts of 2,3-dinor TXB₁ have been identified. In rats, 2,3-dinor TXB₁ is excreted at a much higher rate than 2,3-dinor TXB₂ (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively). Therefore, urinary 2,3-dinor TXB₁ is a suitable marker of thromboxane biosynthesis in rats.