TCO-PEG4-NHS ester
- Product NameTCO-PEG4-NHS ester
- CAS1613439-69-2
- CBNumberCB93062671
- MFC24H38N2O10
- MW514.57
- MDL NumberMFCD28118912
- MOL File1613439-69-2.mol
Chemical Properties
| Density | 1.23±0.1 g/cm3(Predicted) |
| solubility | Soluble in DMSO, DCM, DMF |
| pka | 11.95±0.46(Predicted) |
| InChI | InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1- |
| InChIKey | ZKPMRASGLDBKPF-UPHRSURJSA-N |
| SMILES | C(OC1CCCC=CCC1)(=O)NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O |c:6| |
TCO-PEG4-NHS ester Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| BroadPharm BP-22418 | 10mg | $139 | TCO-PEG4-NHSester 95% |
Buy |
| BroadPharm BP-22418 | 25mg | $235 | TCO-PEG4-NHSester 95% |
Buy |
| BroadPharm BP-22418 | 100mg | $575 | TCO-PEG4-NHSester 95% |
Buy |
TCO-PEG4-NHS ester Chemical Properties,Usage,Production
Description
TCO-PEG4-NHS Ester is a click chemistry crosslinker. This reagent can be used to label antibodies, proteins and other primary amine containing molecule. The hydrophilic PEG spacer increases water-solubility and decreases steric hindrance during ligation. TCO enable fast click chemistry under mild conditionBiological Activity
TCO-PEG4-NHS ester is a PROTAC linker and belongs to the PEG class,it can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
