ChemicalBook CAS DataBase List TCO-PEG4-NHS ester

TCO-PEG4-NHS ester

Product NameTCO-PEG4-NHS ester
CAS1613439-69-2
CBNumberCB93062671
MFC24H38N2O10
MW514.57
MDL NumberMFCD28118912
MOL File1613439-69-2.mol

Chemical Properties

Density	1.23±0.1 g/cm3(Predicted)
solubility	Soluble in DMSO, DCM, DMF
pka	11.95±0.46(Predicted)
form	Oil
color	Colorless to light yellow
InChI	InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1-
InChIKey	ZKPMRASGLDBKPF-UPHRSURJSA-N
SMILES	C(OC1CCCC=CCC1)(=O)NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O \|c:6\|

TCO-PEG4-NHS ester Price

Product number	Packaging	Price	Product description	Buy
BroadPharm BP-22418	10mg	$139	TCO-PEG4-NHSester 95%	Buy
BroadPharm BP-22418	25mg	$235	TCO-PEG4-NHSester 95%	Buy
BroadPharm BP-22418	100mg	$575	TCO-PEG4-NHSester 95%	Buy

TCO-PEG4-NHS ester Chemical Properties,Usage,Production

Description

TCO-PEG4-NHS Ester is a click chemistry crosslinker. This reagent can be used to label antibodies, proteins and other primary amine containing molecule. The hydrophilic PEG spacer increases water-solubility and decreases steric hindrance during ligation. TCO enable fast click chemistry under mild condition

Biological Activity

TCO-PEG4-NHS ester is a PROTAC linker and belongs to the PEG class,it can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Preparation Products And Raw materials

TCO-PEG4-NHS ester Suppliers

Cleavable

PEGs

Supplier	Tel	Email	Country	ProdList	Advantage
Xian confluore Biological Technology Co., Ltd.	+86-15680926068 +86-15680926068	1924344760@confluore.cn	China	2996	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3148	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
Shanghai Huici Pharmaceutical Technology Co., LTD	+8618917134367	lixing@pharmahuici.com	China	133	58
Shanghai Huici Pharmaceutical Technology Co., LTD	+8618917134367	lixing@pharmahuici.com	China	133	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4825	58
Borenpharm Co., Ltd	027-65563561	sales@borenpharm.com	China	1245	55

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