TCO-PEG3-Amine

Description

TCO-PEG3-amine is a click chemistry crosslinking reagent. It can be used to derivatize NHS activated esters through a stable amide bond or carboxyl groups in the presence of of activators (e.g. EDC, or HATU). TCO enable click chemistry with tetrazine. PEG spacer improves water solubility.

Uses

TCO-C3-PEG3-C3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005