Synthesis
Take 0.1 mol of 2,5-dichloroaniline, add 9 ml of HCl and 25 ml of water, and heat the solution in a round-bottom flask at about 60-70°C for about 1 hour. Cool the mixture for about 1 hour, and then slowly add 0.1 mol of ammonium thiocyanate to the solution. Now reflux the solution for about 4 hours. Add 20 ml of water to the solution while stirring constantly. Filter the solution and dry to obtain powdered 2,5-dichlorophenylthiourea.
Uses
2,5-Dichlorophenylthiourea is a pharmaceutical intermediate that can be prepared in one step from 2,5-dichloroaniline. Literature reports that 2,5-dichlorophenylthiourea can be used to prepare the bactericidal compound N-(2,5-dichlorophenyl)-4-(pyridin-2-yl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amine.
Application
Zhang Mu et al. reported that 2,5-dichlorophenylthiourea can be used to prepare the following 2-aminothiazole derivative compound, 6hN-(2,5-dichlorophenyl)-4-(pyridin-2-yl)-5-(1H-1,2,4-triazol-1-yl)thiazole-2-amine. 2-Aminothiazole derivatives not only possess excellent insecticidal, fungicidal, herbicidal, and plant growth-regulating activities, but also exhibit outstanding pharmacological activities. Due to their simple synthetic methods and diverse biological activities, they have attracted considerable attention from pesticide and pharmaceutical researchers.
Chemical Properties
White crystalline powder
