TAN 1364B, CI 010
- Product NameTAN 1364B, CI 010
- CAS332131-32-5
- CBNumberCB92703759
- MFC21H38CaO5
- MW410.61
- MDL NumberMFCD00942285
- MOL File332131-32-5.mol
Chemical Properties
storage temp. | Store at -20°C |
solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble |
form | A solid |
TAN 1364B, CI 010 Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
Cayman Chemical 19450 | 500μg | $242 | RK-682 (calcium salt) ≥95% |
Buy |
Cayman Chemical 19450 | 2.5mg | $1148 | RK-682 (calcium salt) ≥95% |
Buy |
TRC R550003 | 200μg | $95 | RK-682 |
Buy |
TRC R550003 | 400μg | $150 | RK-682 |
Buy |
AK Scientific 5153ED | 2.5mg | $1375 | Calcium;(2R)-4-hexadecanoyl-2-(hydroxymethyl)-5-oxo-2H-furan-3-olate |
Buy |
TAN 1364B, CI 010 Chemical Properties,Usage,Production
Description
Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. RK-682, a bioactive compound originally isolated from the fermentation of Streptomyces sp. 88-682, is an inhibitor of the PTPs. It inhibits the phosphorylation of CD45 and VHR with IC50 values of 54 and 2 μM, respectively, and arrests cell cycle progress at the G1/S transition. It is also reported to inhibit heparanase (IC50 = 17 μM), an endo-β-D-glucuronidase involved in tumor cell invasion and angiogenesis. RK-682 (calcium salt) is a less soluble version of the free acid.Uses
RK-682 is a dimeric calcium complex of the major analogue of tetronic acid complex isolated from Streptomyces. Although reported by researchers at RIKEN in 1995, subsequent synthesis in 2001 showed that RK-682 was in fact the calcium complex formed during silica chromatography. Confusion about the structure of RK-682 has lead to the monomeric sub-unit, TAN 1364B (3-hexadecanoyl-5-hydroxymethyltetronic acid) being mis-named as RK-682 by many suppliers. As either the dimer or monomer, RK 682 inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease. However, is unclear whether biological activity is due to the monomer (TAN 1364B) or dimeric complex (RK-682).Uses
RK-682 is a specific PTP1B inhibitor.Uses
RK-682 is a dimeric calcium complex of the major analogue of a tetronic acid complex isolated from Streptomyces. Although reported by researchers at RIKEN in 1995, subsequent synthesis in 2001 showed that RK-682 was in fact the calcium complex formed during silica chromatography. Confusion about the structure of RK-682 has lead to the monomeric sub-unit, TAN 1364B (3-hexadecanoyl-5-hydroxymethyltetronic acid) being mis-named as RK-682 by many suppliers. As either the dimer or monomer, RK-682 inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease. However, is unclear whether biological activity is due to the monomer (TAN 1364B) or dimeric complex (RK-682).Preparation Products And Raw materials
TAN 1364B, CI 010 Suppliers
Global(20)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
+1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32165 | 58 | |
16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19741 | 58 | |
+1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 | |
86-(0)29-85992781 17792393971 |
info@lynnchem.com | China | 4587 | 58 | |
44-20819178-90 02081917890 |
info@novachemistry.com | United Kingdom | 4381 | 58 | |
400-9205774 | sales@glpbio.cn | China | 6777 | 58 | |
+86-400-002-6226 +86-13028896684; |
sales@rrkchem.com | China | 57412 | 58 | |
18818260767 | sales@chemegen.com | China | 11217 | 58 | |
400-820-6829 | sales@mitachieve.com | China | 8860 | 58 | |
4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
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