2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride

Description

ABT-724 is a dopamine D₄ receptor agonist with an EC₅₀ value of 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D_4.4 receptor and Gα_qo5. It is selective for dopamine D₄ over D₂ receptors at 10 μM. ABT-724 (0.03 μmol/kg) induces penile erections in 77% of male rats. It decreases mounting frequency and ejaculation latency and increases ejaculation frequency and copulatory efficacy in male rats when administered at a dose of 0.04 mg/kg. ABT-724 (0.16 and 0.64 mg/kg) decreases hyperactivity and exploratory behavior in the open field test in an adolescent spontaneously hypertensive rat (SHR) model of attention-deficit hyperactivity disorder (ADHD).

storage

+4°C (desiccate)

References

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