N1-[2-(ACETYLAMINO)PHENYL]ACETAMIDE

Synthesis

108-24-7

88-74-4

2050-85-3

As a representative example, a mixture of 2-nitroaniline (1 mmol), Ni2B-Cu2O (54 mg), a drop of distilled water and NaBH4 (2.5 mmol) was ground in a porcelain mortar with a pestle and pestle for one minute at room temperature. Subsequently, acetic anhydride (1 mmol) was slowly added drop by drop and the reaction mixture was continued to be ground in an oil bath at 40 °C for one minute. Upon completion of the reaction, the progress of the reaction was verified by thin layer chromatography (TLC) using hexane: EtOAc: MeOH (5:3:1) as the unfolding agent. After cooling the reaction mixture to room temperature, 5 mL of distilled water was added to the reaction vessel. Subsequently, the reaction mixture was transferred to a 25 mL flask equipped with a magnetic stirrer and stirred vigorously for 2 min. The product was extracted with dichloromethane (5 x 9 mL) and the organic phases were combined and dried with anhydrous sodium sulfate. The dried organic phase was filtered through a cotton filter and the solvent was evaporated to give N,N'-(1,2-phenylene)diethylamide in 98% yield.

References