Pyrasulfotole

Uses

Pyrasulfotole (P847008) is a 4-hydroxyphenylppvate dioxygenase (HPPD) inhibitor herbicide, used in controlling post-emergence weeds in small grains cultures.

Production Methods

Pyrasulfotole is commercially synthesised by coupling a pyrazole derivative with a trifluoromethyl-substituted benzenesulfonyl chloride, producing a selective herbicide used in cereal crops. The production process begins with the preparation of 5-hydroxy-1,3-dimethylpyrazole, which serves as the core heterocyclic scaffold. This intermediate undergoes acylation with 2-(methylsulfonyl)-4-(trifluoromethyl)benzoyl chloride, forming the final active ingredient.

Definition

ChEBI: Pyrasulfotole is a pyrazole pesticide that is 1,3-dimethylpyrazol-5-ol in thich the hydrogen at position 4 has been replaced by a 2-(methylsulfonyl)-4-(trifluoromethyl)benzoyl group. A 4-hydroxyphenylpyruvate dioxygenase inhibitor, it is used as a herbicide (particularly in conjunction with the safener mefenpyr-diethyl) to control various broad-leaved weeds. It has a role as a herbicide, a carotenoid biosynthesis inhibitor, an EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor and an agrochemical. It is a pyrazole pesticide, an aromatic ketone, a sulfone and a member of (trifluoromethyl)benzenes.

Mechanism of action

Selective, acts by the inhibition of carotenoid biosynthesis specifically inhibits the enzyme 4- hydroxyphenylpyruvate dioxygenase (HPPD).

Pesticide Type

Herbicide