Synthesis
General procedure for the synthesis of methyl 3-amino-5-cyanobenzoate from methyl 3-cyano-5-nitrobenzoate: 10% Pd/C catalyst (0.9 g) was added to a mixed solution of methanol (200 mL) and tetrahydrofuran (100 mL) containing methyl 3-cyano-5-nitrobenzoate (25 mmol). Subsequently, the reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford methyl 3-amino-5-cyanobenzoate in 95% yield.
References
[1] Patent: US2009/118292, 2009, A1. Location in patent: Page/Page column 29
[2] Chemistry - A European Journal, 2015, vol. 21, # 52, p. 19231 - 19242
[3] Angewandte Chemie - International Edition, 2004, vol. 43, # 48, p. 6649 - 6652
[4] Patent: WO2011/137587, 2011, A1. Location in patent: Page/Page column 55
