Uses
(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde is a reactant involved in organic reactions including:• ;Henry condensation reactions1• ;Synthesis of highly functionalized chiral aziridines2• ;Olefination of aldehydes3• ;C-H oxidations4• ;Aldol-type condensations5• ;Synthesis of hydrophilic pyrazine dyes for use as exogenous fluorescent tracer agents6• ;Hosomi-Sakurai reactions7
Uses
(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxaldehyde_x000D__x000D_Discontinued, Unstable (cas# 15186-48-8) is a compound useful in organic synthesis.
Synthesis
Add 220g of dichloromethane, 23g of bisacetone-D-mannitol, 0.23g of 18-crown-6-ether, and 0.4g of TEMPO to the clean reactor.
0.4g, stirring and mixing well, then slowly lower the temperature to 10 , began to drop the mass percentage of 10wt% of sodium hypochlorite aqueous solution of 72g, drop the process of controlling the temperature of the reaction system in the process of 15 or less, drop after the completion of the reaction to continue the reaction so that the temperature of the temperature in the range of 30 ~ 32 under the conditions of insulation for oxidation reaction 1h, the end of the reaction, static, delamination, to remove the aqueous layer, the collection of the organic layer with 50g of water washed once, layered to remove the water layer, the organic layer collected by adding 20g of anhydrous sodium sulfate and stirring for drying treatment for 30min, filtration, collection of filtrate, the filtrate will be concentrated under reduced pressure to remove the solvent, the wet product obtained after baking, to obtain the dry product (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxaldehyde 22.1g, yield 97%, the content of the gas phase was 99.2%.
