1-Methyl-1H-imidazole-5-carboxylic acid

Chemical Properties

Off-White to tan solid

Uses

1-Methyl-1H-imidazole-5-carboxylic acid serves as a precursor for synthesizing t-butyl ester via esterification in a p-TsCl/pyridine/t-BuOH system, and for preparing N-1-methyl-1H-imidazole-5-acyl-dehydroabietylamine through condensation with dehydroabietylamine[1][2].

Synthesis Reference(s)

Synthesis, p. 767, 1988 DOI: 10.1055/s-1988-27702

References

[1] Collman, J., Zhong, M., Boulatov, R. (2000). Functionalization of 1-methyl-1H-imidazole-5-carboxylic acid at the C-2 position: Efficient syntheses of 2-substituted t-butyl 1-methyl-1H-imidazole-5-carboxylates†. Journal of Chemical Research-s, 222 3 1, 230–231. https://doi.org/10.3184/030823400103167093
[2] Zhao, F., Lu, W., Su, F. (2018). Synthesis and potential antineoplastic activity of dehydroabietylamine imidazole derivatives. MedChemComm, 9 12, 2091–2099. https://doi.org/10.1039/c8md00487k