Palmitoylcarnitine

Uses

C16 Carnitine or palmitoyl L-carnitine has been used to study its influence on the glycine transporters activity.

Definition

ChEBI: An O-acylcarnitine having palmitoyl (hexadecanoyl) as the acyl substituent.

Biological Activity

C16 Carnitine has a potential to inhibit glycine transporter 2 (GlyT2). It acts as a key energy donor for β-oxidation. Palmitoyl carnitine activates the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum. Elevated levels of palmitoyl L-carnitine due to palmitoyl transferase II deficiency causes autosomal recessive disorder of energy metabolism, which primarily affects skeletal muscle.