Sevelamer hydrochloride
- Product NameSevelamer hydrochloride
- CAS152751-57-0
- CBNumberCB91012045
- MFC6H13Cl2NO
- MW186.08
- EINECS682-522-4
- MOL File152751-57-0.mol
- MSDS FileSDS
Chemical Properties
storage temp. | Store at -20°C |
solubility | Hot Methanol (Sparingly) |
form | Solid |
color | Pale Yellow |
FDA UNII | GLS2PGI8QG |
Sevelamer hydrochloride Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
TRC S256000 | 500mg | $225 | SevelamerHydrochloride(TechnicalGrade) |
Buy |
AK Scientific E121 | 500mg | $225 | Sevelamerhydrochloride |
Buy |
ChemScene CS-3149 | 500mg | $324 | Sevelamerhydrochloride >98.0% |
Buy |
ChemScene CS-3149 | 100mg | $90 | Sevelamerhydrochloride >98.0% |
Buy |
Sevelamer hydrochloride Chemical Properties,Usage,Production
Originator
Renagel,Chugai PharmaceuticalUses
Sevelamer HCl is used in the treatment of hyperphosphataemia in patients suffering from chronic kidney disease.Uses
Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure or patients suffering from chronic kidney disease.Definition
ChEBI: Sevelamer hydrochloride is an epoxide.Manufacturing Process
Poly(allylamine hydrochloride) (50% w/w, 426 kg) was charged to a 1000 L reactor and water (200 L) was added. Sodium hydroxide solution (32% w/w, 208 kg) was added, followed by 85 L of water. The mixture was stirred for 1 h and filtered to a 2500 L reactor. The transfer line was rinsed with water (217 kg) and acetonitrile (1300 L) added. The temperature was adjusted to 40°C and epichlorohydrin (20 kg) added. The mixture was stirred at 40° to 50°C for 1.5 h and then heated to reflux for 16 h. The resulting product slurry may be isolated and washed in decanter centrifuge.brand name
Renagel (Genzyme).Therapeutic Function
AntihyperphosphatemicVeterinary Drugs and Treatments
Sevalamer may be useful for treating hyperphosphatemia associated with chronic renal failure, particularly when oral aluminum salts are not tolerated.Preparation Products And Raw materials
Raw materials
Sevelamer hydrochloride Supplier
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