3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-6-CARBOXYLIC ACID

Uses

HIP-B is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker. It can also be used as AMPA-Kainate receptor agonists.

Biological Activity

Potent, non-competitive excitatory amino acid transporter (EAAT) blocker. Preferentially inhibits glutamate-induced [ 3 H]D-aspartate release (IC 50 = 1.2 μ M) rather than [ 3 H]L-glutamate uptake (IC 50 = 16.9 μ M). Moderately selective; displays no affinity for NMDA and metabotropic glutamate receptors, and low affinity for AMPA and kainate receptors (IC 50 values are 35 and 45 μ M respectively).