Lobeline (0.3-3.0 mg/kg; s.c.; single dose) sulfate decreases d-methamphetamine self-administration in rats model[3].
Lobeline (3 mg/kg; s.c.; 7 times during 7 sessions) sulfate specifically decreases responding for d-Methamphetamine in a noncompetitive manner, and increases tolerance development[3].
| Animal Model: | Sprague-Dawley rats (200-250 g)[3] |
| Dosage: | 0.3 mg/kg, 1.0 mg/kg, and 3.0 mg/kg for acute administration; 3 mg/kg for chronic administration |
| Administration: | Subcutaneous injection; 15 min prior to measurement, or every 15 min for 7 sessions; separated by 2 intervening maintenance days of d-methamphetamine (0.05 mg/kg/infusion) self-administration |
| Result: | Decreased d-methamphetamine Self-Administration. |
