Uses
Margatoxin is a highly pure, synthetic, and biologically active peptide toxin.
Uses
Margatoxin, Recombinant is a specific blocker of Kv1.3, Kv1.6 channels.
Biochem/physiol Actions
Margatoxin is an α-KTx toxin, which is majorly used in ion channel research. It is a 39-amino acid peptide, which is a specific K(V)1.3 channel voltage-dependent K+ channel blocker. Margatoxin is an immunosuppressant that is isolated from the venom of the scorpion Centruroides margaritatus.
in vivo
Margatoxin (i.p.; 1 pmol/g) significantly decreases thiogycollate-induced leukocyte transmigration in the peritoneal cavity in 12-week-old C57BL6/J mice[2].
