Uses
2-Naphthyl Butyrate (cas# 5856-33-7) is a compound useful in organic synthesis.
Definition
ChEBI: 2-naphthyl butyrate is a butyrate ester obtained by formal condensation of the carboxy group of butyric acid with the hydroxy group of 2-naphthol. It has a role as a chromogenic compound. It is a member of naphthalenes, a butyrate ester and an aromatic ester. It is functionally related to a 2-naphthol.
Synthesis
The general procedure for the synthesis of 2-naphthyl butyrate from 2-naphthol and vinyl n-butyrate was as follows: a mixture of 2-naphthol (0.50 mmol), Na2CO3 (10.6 mg, 0.10 mmol, 20 mol%), and vinyl n-butyrate (2.0 mmol, 4.0 eq.) in acetonitrile (3 mL) was added to a 25 mL Schlenk flask. The reaction mixture was stirred at 120 °C until the reaction was complete. Subsequently, the solvent was removed by distillation under reduced pressure and the residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate from 20:1 to 10:1) to afford the target product 2-naphthyl butyrate.
References
[1] Synlett, 2018, vol. 29, # 17, p. 2321 - 2325
