Uses
WJ460 is a potent inhibitor of myoferlin (MYOF) that interacts directly with MYOF. WJ460 inhibits the migration and growth, induces cell cycle arrest, mitochondrial autophagy, lipid peroxidation and ferroptosis in tumor cells. WJ460 has anti-tumor activity[1][2].
in vivo
WJ460 (5-10mg/kg; intraperitoneal injection; single dose) has antitumor activity in nude mouse breast cancer metastasis model[2].
| Animal Model: | MDA-MB-231-Luciferase cells treated athymic nude mice[2] |
| Dosage: | 5 and 10mg/kg |
| Administration: | Intraperitoneal injection (i.p.); single dose |
| Result: | Significantly inhibited breast cancer pulmonary metastasis in a concentration-dependent manner.
Inhibited the proliferation of MDA-MB-231 cells.
Increased mouse overall survival. |
References
[1] Rademaker G, et al. Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. Redox Biol. 2022 Jul;53:102324. DOI:
10.1016/j.redox.2022.102324[2] Zhang T, et al. A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer. Nat Commun. 2018 Sep 13;9(1):3726. DOI:
10.1038/s41467-018-06179-0
