TRANS-PERMETHRIN D6 (DIMETHYL D6)

Uses

Permethrin-d6 (NRDC-143-d6) is deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes)[1][2][3][4][5][6][7].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Xiao X, et al. Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice. Food Chem Toxicol. 2018 Jan;111:405-416. DOI:10.1016/j.fct.2017.11.047
[3] Smith LB, et al. CYP-mediated permethrin resistance in Aedes aegypti and evidence for trans-regulation. PLoS Negl Trop Dis. 2018 Nov 19;12(11):e0006933. DOI:10.1371/journal.pntd.0006933
[4] Shelley LK, et al. Immunotoxic and cytotoxic effects of atrazine, permethrin and piperonyl butoxide to rainbow trout following in vitro exposure[J]. Fish Shellfish Immunol. 2012 Aug;33(2):455-8. DOI:10.1016/j.fsi.2012.05.020
[5] Gassner B, et al. The pyrethroids permethrin and cyhalothrin are potent inhibitors of the mitochondrial complex I[J]. Journal of Pharmacology and Experimental Therapeutics, 1997, 281(2): 855-860. PMID:9152394
[6] Kakko I, et al. The synaptosomal membrane bound ATPase as a target for the neurotoxic effects of pyrethroids, permethrin and cypermethrin[J]. Chemosphere. 2003 May;51(6):475-80. DOI:10.1016/S0045-6535(02)00854-8
[7] Brander SM, et al. The in vivo estrogenic and in vitro anti-estrogenic activity of permethrin and bifenthrin. Environ Toxicol Chem. 2012 Dec;31(12):2848-55. DOI:10.1002/etc.2019
[8] Omotoso G, et al. Permethrin exposure affects neurobehavior and cellular characterization in rats' brain. Environ Anal Health Toxicol. 2020 Dec;35(4):e2020022-0. DOI:10.5620/eaht.2020022