DALDA (0-7 nmol/rat; i.t.; once) shows antinociceptive and respiratory effects in rats[1].
DALDA (0.1 and 1.0 μg/side; ICV; once) results in biphasic effects, with an initial suppression, an intermediate marked inhibition, followed by activation for horizontal movement, rearing and stereotypy times in rats[2].
| Animal Model: | Male Sprague-Dawley rats (300–350 g)[1] |
| Dosage: | 0.24, 0.7 and 7 nmol/rat |
| Administration: | Intrathecal injection, once |
| Result: | Showed antinociceptive effects with an ED50 of 237 pmol/rat in the rat tail-flick test. Inhibited the uptake of NE in spinal cord synaptosomes in a dose-dependent manner. Had no effect on 5-HT uptake. Produced depression in minute ventilation. |
| Animal Model: | Male Long-Evans rats, weighing 200-225 g[2] |
| Dosage: | 0, 0.1 and 1.0 μg/side, 0.5 μL |
| Administration: | Lateral cerebral ventricle injection, once |
| Result: | Elicited a significant biphasic effect with an initial suppression, an intermediate marked inhibition, followed by significant activation for horizontal movement time, rearing time, and stereotypy time. |
