Uses
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM[1]. CH 275 acts as a potent and selective sst1agonist (IC50=30.9 nM) and also displaysIC50values of 345 nM, >1μM, >10μM, >10μM for human sst3, sst4, sst2and sst5,respectively[2]. CH 275 can be used for the research of alzheimer’s disease[3].
References
[1] L Chen, et al. Structural basis for the binding specificity of a SSTR1-selective analog of somatostatin. Biochem Biophys Res Commun. 1999 May 19;258(3):689-94. DOI:
10.1006/bbrc.1999.0699[2] J E Rivier, et al. Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J Med Chem. 2001 Jun 21;44(13):2238-46. DOI:
10.1021/jm010037+[3] PerNilsson,et al. Somatostatin receptor subtypes 1 and 4 redundantly regulate neprilysin, the major amyloid β-degrading enzyme, in brain.
