Description
MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable.
Chemical Properties
yellow powder
Uses
MDBN is a Src and Syk kinase inhibitor that prevents phosphorylation and cytoskeletal association of GPIIb/IIIa and talin.
Biological Activity
Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC 50 = 12.7 μ M for thrombin-induced platelet aggregation). Exhibits no effects on Ca 2+ -dependent enzymes, PKC or arachidonic acid metabolism.
References
1) Chou et al. (2011), Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system; J. Biol. Chem., 286 16546
